I'm of the mindset now, that I will pretty much take a 3080 or 6900xt, whichever is available first.
That will then dictate the rest of the upgrade.
3080 = Z490+10850K
6900XT = X570 + 5900X
I may take a stab at water cooling too, haven't done that in the 30 years I've been dicking around with this shit.
If you want a laugh, google "MO-RA3 Radiator", as it's the one I'm looking at. Why that one? Because, fuck it, that's why.